Djävulsklo – dokumenterad effekt mot artros

Var fjärde svensk över 45 år beräknas lida av artros i någon form. Det gör artros till den vanligaste ledsjukdomen och för många leder besvären till svår smärta i knän, höfter, rygg, fingrar och tår. Men det finns hjälp att få – utan risk för besvärliga biverkningar.

28 augusti, 2022

Artros kommer ofta smygande och problemen ökar i takt med ålder och belastning av leder, För många innebär stelheten, smärtan och den försämrade rörligheten som förknippas med artros till kraftigt försämrad livskvalitet. Det finns ingen behandling som bromsar utvecklingen av artros. Däremot finns det olika möjligheter att minska smärtan och därmed bibehålla en bättre funktion i leden, dels med läkemedel, dels med träning för att stärka muskulaturen kring leden.

Slipper besvärliga biverkningar

Ett problem med de vanligaste läkemedlen vid lindrigare former av artros (paracetamol och NSAID) är att de inte bör användas vid långtidsbehandling och att de inte sällan leder till besvärliga biverkningar ibland annat mage och tarm. För många artrosdrabbade är denna typ av läkemedel helt enkelt inte är ett fungerande alternativ för att lindra ledsmärta vid artros.

Ett alternativ kan då vara att prova med växtbaserade läkemedel med snällare biverkningsprofil. Nyligen lanserades FlexiLoges i Sverige, ett traditionellt växtbaserat läkemedel baserat på läkeörten djävulsklo.

Det finns gott om naturliga alternativ för dig som lider av artros och smärtande leder.

Väl dokumenterat

Djävulsklo har använts under lång tid för behandling av smärta vid olika typer av ledbesvär och är väl dokumenterat i olika studier relaterade till artros. Läkemedelsverket har registrerat Flexiloges, som innehåller extrakt av djävulsklo, som ett traditionellt växtbaserat läkemedel på indikationen ”lindring av smärta vid lätt ledförslitning (artros)”.

Det finns ett stort antal referenser till genomförda studier på användning av extrakt från djävulsklo vid behandling av smärta vid artros samt rygg- och muskelbesvär. Totalt handlar det om drygt 130 studier kliniska studier gjorda från 1980 och framåt där effekter och säkerhet vid behandling med djävulsklo jämförts både med placebo och andra konventionella läkemedel som NSAID. I de flesta studierna har extrakt av djävulsklo visat minst lika god effekt som NSAID – fast utan de besvärliga biverkningar som ofta följer med antiinflammatoriska läkemedel.

Halvering av smärtan

I en öppen studie på patienter med knä- och höftartros påvisades en minskning av ledsmärtan med i genomsnitt 34 % efter 4 veckors behandling med djävulsklo och hela 52% efter 8 veckor. 95 % av deltagarna, varav många haft besvär med biverkningar från NSAID, angav att de tolererade djävulsklo bra eller mycket bra. I andra studier på ryggsmärta noterades en markant förbättring hos de patienter som fick extrakt av djävulsklo jämfört med placebogruppen. I ett antal andra randomiserade studier har djävulsklo visat sig fungera signifikant bättre än placebo och varit minst lika effektiv som konventionella kemiska preparat – fast med betydligt snällare biverkningsprofil.

Extraktet i Flexiloges utvinns ur roten från djävulsklo.

Expertens kommentar

”Det finns en mängd bra kliniska studier gjorda på harpagosider och djävulskloextraktets antiinflammatoriska och smärtstillande effekter”. Sammantaget styrker de användningen av djävulsklo vid artros och ryggskott.”

Jan G Bruhn, farm dr i farmakognosi, om djävulsklo i läroboken ”Läkemedel från naturen – en integrerad del av medicinen”.

Andra växtbaserade alternativ vid artros

Det finns flera läkeörter som kan fungera som växtbaserade alternativ till paracetamol och NSAID vid artros och muskelsmärta. Bland dessa märks extrakt av gurkmeja, ingefära, nyponextrakt och boswellia. curaMIN Forte innehåller exempelvis en optimerad kombination av gurkmeja och boswellia och Nypozin innehåller nyponextrakt och C-vitamin. Extrakt från den nyzeeländska grönläppade musslan (finns i kosttillskottet Glyc) har i studier visat sig ha god effekt mot smärta och stelhet i samband med artros.

Fakta

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value<p><strong>Växtfakta</strong>: Djävulsklo, Harpagophytum procumbens DC</p>
<p><strong>Ursprung: </strong>Djävulsklo är en läkeört med rötter i traditionell medicin i södra Afrika.</p>
<p><strong>Användningsområde: </strong>Har använts traditionellt mot åkommor som feber, magsår, och mensvärk, men har på senare år framförallt kommit att fungera som ett naturligt alternativ mot smärta vid artrit/artros, muskelsmärtor och ryggvärk. Flexiloges är utformat för användning vid långvarig led- och muskelsmärta och värt att understryka är att det ofta tar 14–28 dagar innan full effekt uppnås.</p>
<p><strong>Finns i: </strong>Det traditionella växtbaserade läkemedlet Flexiloges.</p>
<p><strong>Innehåll: </strong>Flexiloges är ett traditionellt växtbaserat läkemedel från tyska Dr. Loges. Kapslarna innehåller torkat rotextrakt av djävulsklo.</p>
<p><strong>Biverkningar: </strong>Få biverkningar har rapporterats, men medel med djävulsklo ska ej användas om du har magsår.</p>
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Växtfakta: Djävulsklo, Harpagophytum procumbens DC

Ursprung: Djävulsklo är en läkeört med rötter i traditionell medicin i södra Afrika.

Användningsområde: Har använts traditionellt mot åkommor som feber, magsår, och mensvärk, men har på senare år framförallt kommit att fungera som ett naturligt alternativ mot smärta vid artrit/artros, muskelsmärtor och ryggvärk. Flexiloges är utformat för användning vid långvarig led- och muskelsmärta och värt att understryka är att det ofta tar 14–28 dagar innan full effekt uppnås.

Finns i: Det traditionella växtbaserade läkemedlet Flexiloges.

Innehåll: Flexiloges är ett traditionellt växtbaserat läkemedel från tyska Dr. Loges. Kapslarna innehåller torkat rotextrakt av djävulsklo.

Biverkningar: Få biverkningar har rapporterats, men medel med djävulsklo ska ej användas om du har magsår.

Execution time: 0.0008 seconds

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Djävulsklo – lindrar smärta vid artros

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<p>Ytterligare information om läkeörten djävulsklo hittar du <a href="https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/harpagophytum">här</a>.</p>
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Här kan du läsa mer om läkeörten djävulsklo och det traditionella växtbaserade läkemedlet Flexiloges.

Ytterligare information om läkeörten djävulsklo hittar du här.

Execution time: 0.0007 seconds

Referenser

ACFID2294
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value<p>Djävulsklo är en av världens bäst dokumenterade läkeörter. Här ett urval av studier och artiklar om djävulsklo.</p>
<ul>
<li><a href="https://www.researchgate.net/publication/23471813_Nitric_oxide_in_inflammation_and_pain_associated_with_osteoarthritis">Abramson SB.</a> Nitric oxide in inflammation and pain associated with osteoarthritis. Arthritis Research & Therapy 2008; 10 Suppl 2.</li>
<li><a href="https://pubmed.ncbi.nlm.nih.gov/19519925/">Abramson SB, Attur M.</a> Developments in the scientific understanding of osteoarthritis. Arthritis Research & Therapy 2009; 11: 227.</li>
<li><a href="https://pubmed.ncbi.nlm.nih.gov/20812280/">Anauate MC, Torres LM, Veríssimo de Mello SB</a>. Effect of Isolated Fractions of Harpagophytum procumbens D.C. (Devil’s Claw) on COX-1, COX-2 Activity and Nitric Oxide Production on Whole-Blood Assay. Phytother Res 2010; 24: 1365–1369.</li>
<li><a href="https://altmedrev.com/wp-content/uploads/2019/02/v13-3-248.pdf">Anonymous</a>. Harpagophytum procumbens (Devil’s Claw). Alternative Medicine Review 2008; Volume 13, Number 3, pp 248–252.</li>
<li>Bélaiche P. Étude clinique de 630 cas d’arthrose traits par le nébulisant aqueux d’Harpagophytum procumbens (Radix).Conférence faite au III Congrès International de Phytothérapie à Paris, Octobre 1981.</li>
<li><a href="https://www.mdpi.com/1424-8247/14/8/726">Brendler T.</a> From Bush medicine to Modern Phytopharmaceutical: A Bibliographic Review. <span role="menubar"><a role="menuitem" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398729/#" aria-expanded="false" aria-haspopup="true">Pharmaceuticals (Basel).</a></span> 2021 Aug; 14(8): 726.</li>
<li>Brendler T, Gruenwald J, Ulbricht C, Basch E. Devil’s Claw (Garpagophytum procumbens DC): An evidence-based systematic review by the Natural Standard Research Collaboration. Journal of Herbal Pharmacitherapy 2006; vol 6(1).</li>
<li><a href="https://pubmed.ncbi.nlm.nih.gov/17212570/">Brien S, Lewith GT, McGregor G.</a> Devil’s Claw (Harpagophytum procumbens) as a treatment for osteoarthritis: A review of efficacy and safety. The Journal of Alternative abd Complementary Medicine 2006; vol 12, no 10, pp 981-993.</li>
<li><a href="https://pubmed.ncbi.nlm.nih.gov/19856319/">Cameron M, Gagnier JJ, Little CV, Parsons TJ, Blümle A, Chrubasik S</a>. Evidence of effectiveness of herbal medicinal products in the treatment of arthritis. Phytotherapy research 2009; 23: 1497-1515.</li>
<li>Chantre P, Cappelaere A, Leblan D, Guedon D, Vandermander J, Fournie B. Efficacy and tolerance of Harpagophytum procumbens versus diacerhein in treatment of osteoarthritis. Phytomedicine 2000; vol 7(3), pp 177-183.</li>
<li>Chrubasik S, Zimpfer CH, Schütt U, Ziegler R. Effectiveness of Harpagophytum procumbens in treatment of acute low back pain. Phytomedicine 1996; vol 3(1), pp 1-10.</li>
<li>Chrubasik S, Thanner J, Künzel O, Conradt C, Black A, Pollak S. Comparison of outcome measures during treatment with the proprietary Harpagophytum extract Doloteffin® in patients with pain in the lower back, knee or hip. Phytomedicine 2002; 9: 181-194.</li>
<li>Chrubasik S, Junck H, Breitschwerdt H, Conradt Ch, Zappe H. Effectiveness of Harpagophytum extract WS 1531 in the treatment of exacerbation of low back pain: a randomized, placebo-controlled, double-blind study. European Journal of Anaesthesiology 1999; 16: 118-129.</li>
<li>Chrubasik S, Schmidt A, Junck H, Pfisterer M. Wirksamkeit und Wirtschaftlichkeit von Teufelskrallenwurzelextrakt bei rückenschmerzen: Erste ergebnisse einer therapeutischen kohortenstudie. Forsch Komplementärmed 1997, 4: 332-336.</li>
<li>Cordier W, Steenkamp V. Drug interactions in African herbal remedies. Drug Metab Drug Interact 2011; 26(2).</li>
<li>Eklund Å. Harpagophytum procumbens – Djävulsklo. Institutionen för läkemedelskemi, Avdelningen för farmakognosi, Uppsala universitet, 2006.</li>
<li>Frerick H, Biller A, Schmidt U. Stufenschema bei coxarthrose. Doppelblindstudie mit Teufelskralle. Kassenartzt 2001; 5: 31-34.</li>
<li>Frerick H, Biller A, Schmidt U. Double-blind study with Devil’s claw – graduated treatment regimen in osteoarthritis of the hip. Interdisciplinary Medical Research Organisation, Cologne and Dr. Loges + Co GmbH Arzneimittel, Winsen.</li>
<li>Gagnier JJ, Chrubasik S, Manheimer E. Harpgophytum procumbens for osteoarthritis and low back pain: A systematic review. BMC Complementary and Alternative Medicine 2004; 4: 13.</li>
<li>Gagnier JJ, van Tulder MW, Berman B, Bombardier C. Herbal Medicine for Low Back Pain. A Cochrane Review. Spine 2007; 32(1): 82-92.</li>
<li>Georgiev MI, Alipieva K, Orhan IE. Cholinesterases inhibitory and antioxidant activities of Harpagophytum procumbens from in vitro systems. Phytotherapy research 2011 (Wiley Online Library).</li>
<li>Göbel H, Heinze A, Ingwersen M, Niederberger U, Gerber D. Harpagophytum-extrakt LI 174 (Teufelskralle) bei der Behandlung unspezifischer Rückenschmerzen. Schmerz 2001; 15: 10-18.</li>
<li>Haglund O. Djävulsklo – ett spännande alternativ vid ledbesvär. Medicinsk access 2009; 1: 44-47.</li>
<li>Haglund O. Artros – den dolda folksjukdomen. Medicinsk access 2008; 6: 20-26.</li>
<li>HancockCM, Riegger-Krugh C. Modulation of Pain in Osteoarthritis. The Role of Nitric Oxide. Clin J Pain 2008; 24(4): 353-365.</li>
<li>Kaszkin M, Schneider B, Loew D. Kasuistik: Hoch dosieerter Harpagophytum-Spezialextrakt zur Remissionserhaltung des Morbus Chrohn. Ärzlezeitschrift für Naturheilverfahren 2004; 45(2): 102-106.</li>
<li>Laudahn D, Walper A. Efficacy and tolerance of Harpagophytum extract LI 174 in patients with chronic non-radicular back pain. Phytotherapy research 2001; 15: 621-624.</li>
<li>Pinget M, Lecomte A. Die Wirkung der “Harpagophytum Arkocaps” bei degenerativen Rheuma. Naturheilpraxix 1997; 2.</li>
<li>Roman-Blas JA, Jimenez SA. NF-kappaB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis. OsteoArthritis and Cartilage 2006; 14: 839-848.</li>
<li>Schendel UM. Arthrose-Therapie: Verträglich geht es auch. Studie mit Teufelskrallenextrakt. Der Kassenarzt 2001; 29/30: 36-39.</li>
<li>Schmelz H, Haemmerle HD, Springorum HW. Analgetische Wirksamkeit eines Teufelskrallenwurzel Extraktes bei verschidenen chronisch-degenerativen Gelenkerkrankungen. Rheumatherapie mit Phytopharmaka. Stuttgart. Hippokrates 1997; 86-89.</li>
<li>Stoltz Denner S. A review of the efficacy and safety of Devil’s Claw for pain associated with degenerative musculoskeletal diseases, rheumatoid, and osteoarthritis. Holistic Nursing Practice 2007; July/August: 203-207.</li>
<li>Warnock M, McBean D, Suter A, Tan J, Whittaker P. Effectiveness and safety of Devil’s Claw tablets in patients with general rheumatic disorders. Phytotherapy Research 2007; 21: 1228-1233.</li>
<li>Wegener T, Lüpke NP. Treatment of patients with arthrosis of hip or knee with an aqueous extract of devil’s claw (Harpagophytum procumbens DC.). Phytotherapy Research 2003; 17(10): 1165-1172.</li>
<li>Vlachojannis J, Roufogalis BD, Chrubasik S. Systematic review on the safety of Harpagophytum preparations for osteoarthritic and low back pain. Phytotherapy Research 2008; 22: 149-152.</li>
</ul>
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Djävulsklo är en av världens bäst dokumenterade läkeörter. Här ett urval av studier och artiklar om djävulsklo.

Abramson SB. Nitric oxide in inflammation and pain associated with osteoarthritis. Arthritis Research & Therapy 2008; 10 Suppl 2.
Abramson SB, Attur M. Developments in the scientific understanding of osteoarthritis. Arthritis Research & Therapy 2009; 11: 227.
Anauate MC, Torres LM, Veríssimo de Mello SB. Effect of Isolated Fractions of Harpagophytum procumbens D.C. (Devil’s Claw) on COX-1, COX-2 Activity and Nitric Oxide Production on Whole-Blood Assay. Phytother Res 2010; 24: 1365–1369.
Anonymous. Harpagophytum procumbens (Devil’s Claw). Alternative Medicine Review 2008; Volume 13, Number 3, pp 248–252.
Bélaiche P. Étude clinique de 630 cas d’arthrose traits par le nébulisant aqueux d’Harpagophytum procumbens (Radix).Conférence faite au III Congrès International de Phytothérapie à Paris, Octobre 1981.
Brendler T. From Bush medicine to Modern Phytopharmaceutical: A Bibliographic Review. Pharmaceuticals (Basel). 2021 Aug; 14(8): 726.
Brendler T, Gruenwald J, Ulbricht C, Basch E. Devil’s Claw (Garpagophytum procumbens DC): An evidence-based systematic review by the Natural Standard Research Collaboration. Journal of Herbal Pharmacitherapy 2006; vol 6(1).
Brien S, Lewith GT, McGregor G. Devil’s Claw (Harpagophytum procumbens) as a treatment for osteoarthritis: A review of efficacy and safety. The Journal of Alternative abd Complementary Medicine 2006; vol 12, no 10, pp 981-993.
Cameron M, Gagnier JJ, Little CV, Parsons TJ, Blümle A, Chrubasik S. Evidence of effectiveness of herbal medicinal products in the treatment of arthritis. Phytotherapy research 2009; 23: 1497-1515.
Chantre P, Cappelaere A, Leblan D, Guedon D, Vandermander J, Fournie B. Efficacy and tolerance of Harpagophytum procumbens versus diacerhein in treatment of osteoarthritis. Phytomedicine 2000; vol 7(3), pp 177-183.
Chrubasik S, Zimpfer CH, Schütt U, Ziegler R. Effectiveness of Harpagophytum procumbens in treatment of acute low back pain. Phytomedicine 1996; vol 3(1), pp 1-10.
Chrubasik S, Thanner J, Künzel O, Conradt C, Black A, Pollak S. Comparison of outcome measures during treatment with the proprietary Harpagophytum extract Doloteffin® in patients with pain in the lower back, knee or hip. Phytomedicine 2002; 9: 181-194.
Chrubasik S, Junck H, Breitschwerdt H, Conradt Ch, Zappe H. Effectiveness of Harpagophytum extract WS 1531 in the treatment of exacerbation of low back pain: a randomized, placebo-controlled, double-blind study. European Journal of Anaesthesiology 1999; 16: 118-129.
Chrubasik S, Schmidt A, Junck H, Pfisterer M. Wirksamkeit und Wirtschaftlichkeit von Teufelskrallenwurzelextrakt bei rückenschmerzen: Erste ergebnisse einer therapeutischen kohortenstudie. Forsch Komplementärmed 1997, 4: 332-336.
Cordier W, Steenkamp V. Drug interactions in African herbal remedies. Drug Metab Drug Interact 2011; 26(2).
Eklund Å. Harpagophytum procumbens – Djävulsklo. Institutionen för läkemedelskemi, Avdelningen för farmakognosi, Uppsala universitet, 2006.
Frerick H, Biller A, Schmidt U. Stufenschema bei coxarthrose. Doppelblindstudie mit Teufelskralle. Kassenartzt 2001; 5: 31-34.
Frerick H, Biller A, Schmidt U. Double-blind study with Devil’s claw – graduated treatment regimen in osteoarthritis of the hip. Interdisciplinary Medical Research Organisation, Cologne and Dr. Loges + Co GmbH Arzneimittel, Winsen.
Gagnier JJ, Chrubasik S, Manheimer E. Harpgophytum procumbens for osteoarthritis and low back pain: A systematic review. BMC Complementary and Alternative Medicine 2004; 4: 13.
Gagnier JJ, van Tulder MW, Berman B, Bombardier C. Herbal Medicine for Low Back Pain. A Cochrane Review. Spine 2007; 32(1): 82-92.
Georgiev MI, Alipieva K, Orhan IE. Cholinesterases inhibitory and antioxidant activities of Harpagophytum procumbens from in vitro systems. Phytotherapy research 2011 (Wiley Online Library).
Göbel H, Heinze A, Ingwersen M, Niederberger U, Gerber D. Harpagophytum-extrakt LI 174 (Teufelskralle) bei der Behandlung unspezifischer Rückenschmerzen. Schmerz 2001; 15: 10-18.
Haglund O. Djävulsklo – ett spännande alternativ vid ledbesvär. Medicinsk access 2009; 1: 44-47.
Haglund O. Artros – den dolda folksjukdomen. Medicinsk access 2008; 6: 20-26.
HancockCM, Riegger-Krugh C. Modulation of Pain in Osteoarthritis. The Role of Nitric Oxide. Clin J Pain 2008; 24(4): 353-365.
Kaszkin M, Schneider B, Loew D. Kasuistik: Hoch dosieerter Harpagophytum-Spezialextrakt zur Remissionserhaltung des Morbus Chrohn. Ärzlezeitschrift für Naturheilverfahren 2004; 45(2): 102-106.
Laudahn D, Walper A. Efficacy and tolerance of Harpagophytum extract LI 174 in patients with chronic non-radicular back pain. Phytotherapy research 2001; 15: 621-624.
Pinget M, Lecomte A. Die Wirkung der “Harpagophytum Arkocaps” bei degenerativen Rheuma. Naturheilpraxix 1997; 2.
Roman-Blas JA, Jimenez SA. NF-kappaB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis. OsteoArthritis and Cartilage 2006; 14: 839-848.
Schendel UM. Arthrose-Therapie: Verträglich geht es auch. Studie mit Teufelskrallenextrakt. Der Kassenarzt 2001; 29/30: 36-39.
Schmelz H, Haemmerle HD, Springorum HW. Analgetische Wirksamkeit eines Teufelskrallenwurzel Extraktes bei verschidenen chronisch-degenerativen Gelenkerkrankungen. Rheumatherapie mit Phytopharmaka. Stuttgart. Hippokrates 1997; 86-89.
Stoltz Denner S. A review of the efficacy and safety of Devil’s Claw for pain associated with degenerative musculoskeletal diseases, rheumatoid, and osteoarthritis. Holistic Nursing Practice 2007; July/August: 203-207.
Warnock M, McBean D, Suter A, Tan J, Whittaker P. Effectiveness and safety of Devil’s Claw tablets in patients with general rheumatic disorders. Phytotherapy Research 2007; 21: 1228-1233.
Wegener T, Lüpke NP. Treatment of patients with arthrosis of hip or knee with an aqueous extract of devil’s claw (Harpagophytum procumbens DC.). Phytotherapy Research 2003; 17(10): 1165-1172.
Vlachojannis J, Roufogalis BD, Chrubasik S. Systematic review on the safety of Harpagophytum preparations for osteoarthritic and low back pain. Phytotherapy Research 2008; 22: 149-152.

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Djävulsklo – dokumenterad effekt mot artros

28 augusti, 2022

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Forskning

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value	<p><a href="https://www.loges.se/produkter/flexiloges?utm_source=naturbiblioteket.se&utm_medium=onlineartikel&utm_campaign=naturbiblioteket">Här</a> kan du läsa mer om läkeörten djävulsklo och det traditionella växtbaserade läkemedlet Flexiloges.</p> <p>Ytterligare information om läkeörten djävulsklo hittar du <a href="https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/harpagophytum">här</a>.</p>
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delay	0
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